(1):

(n.) A mistress of a family, who is a lady; a woman in authority; especially, a lady.

(2):

(n.) A mother; - applied to human beings and quadrupeds.

(3):

(n.) A woman in general, esp. an elderly woman.

(4):

(n.) The mistress of a family in common life, or the mistress of a common school; as, a dame's school.