(1):

(superl.) Hence, hobbling; limping; inefficient; imperfect.

(2):

(superl.) To some degree disabled by reason of the imperfect action of a limb; crippled; as, a lame man.

(3):

(v. t.) To make lame.

(4):

(superl.) Moving with pain or difficulty on account of injury, defect, or temporary obstruction of a function; as, a lame leg, arm, or muscle.