(1):

(v. t.) The act of violating sacred things, or of treating them with contempt or irreverence; irreverent or too familiar treatment or use of what is sacred; desecration; as, the profanation of the Sabbath; the profanation of a sanctuary; the profanation of the name of God.

(2):

(v. t.) The act of treating with abuse or disrespect, or with undue publicity, or lack of delicacy.