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Want to know what the Bible says about Despair? Here are 108 Bible verses about Despair from the Old and New Testaments of the Holy Bible, New International Version (NIV), sorted from the most relevant to the least relevant.

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Note: Always check the context of a verse; Click the "Read Full Chapter" button next to each verse to read more. The context of a verse might put a very different slant on what the verse seems to say.

Isaiah 26:3-4 NIV
3 You will keep in perfect peace
    those whose minds are steadfast,
    because they trust in you.
4 Trust in the Lord forever,
    for the Lord, the Lord himself, is the Rock eternal.
11
Psalm 13:3-6 NIV
3 Look on me and answer, Lord my God.
    Give light to my eyes, or I will sleep in death,
4 and my enemy will say, “I have overcome him,
    and my foes will rejoice when I fall.
5 But I trust in your unfailing love;
    my heart rejoices in your salvation.
6 I will sing the Lord’s praise,
    for he has been good to me.
11
Job 7:6 NIV
“My days are swifter than a weaver’s shuttle,
    and they come to an end without hope.
11
Isaiah 60:1 NIV
“Arise, shine, for your light has come,
    and the glory of the Lord rises upon you.
10
Revelation 9:6 NIV
During those days people will seek death but will not find it; they will long to die, but death will elude them.
10
2 Corinthians 4:10 NIV
We always carry around in our body the death of Jesus, so that the life of Jesus may also be revealed in our body.
10
Matthew 11:28 NIV
“Come to me, all you who are weary and burdened, and I will give you rest.
10
James 4:8 NIV
Come near to God and he will come near to you. Wash your hands, you sinners, and purify your hearts, you double-minded.
10
Psalm 91:1-16 NIV
91 Whoever dwells in the shelter of the Most High
    will rest in the shadow of the Almighty.
2 I will say of the Lord, “He is my refuge and my fortress,
    my God, in whom I trust.”
3 Surely he will save you
    from the fowler’s snare
    and from the deadly pestilence.
4 He will cover you with his feathers,
    and under his wings you will find refuge;
    his faithfulness will be your shield and rampart.
5 You will not fear the terror of night,
    nor the arrow that flies by day,
6 nor the pestilence that stalks in the darkness,
    nor the plague that destroys at midday.
7 A thousand may fall at your side,
    ten thousand at your right hand,
    but it will not come near you.
8 You will only observe with your eyes
    and see the punishment of the wicked.
9 If you say, “The Lord is my refuge,”
    and you make the Most High your dwelling,
10 no harm will overtake you,
    no disaster will come near your tent.
11 For he will command his angels concerning you
    to guard you in all your ways;
12 they will lift you up in their hands,
    so that you will not strike your foot against a stone.
13 You will tread on the lion and the cobra;
    you will trample the great lion and the serpent.
14 “Because he loves me,” says the Lord, “I will rescue him;
    I will protect him, for he acknowledges my name.
15 He will call on me, and I will answer him;
    I will be with him in trouble,
    I will deliver him and honor him.
16 With long life I will satisfy him
    and show him my salvation.
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Genesis 21:14-16 NIV
14 Early the next morning Abraham took some food and a skin of water and gave them to Hagar. He set them on her shoulders and then sent her off with the boy. She went on her way and wandered in the Desert of Beersheba.
15 When the water in the skin was gone, she put the boy under one of the bushes. 16 Then she went off and sat down about a bowshot away, for she thought, “I cannot watch the boy die.” And as she sat there, she began to sob.
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