“The Christian cannot be satisfied so long as any human activity is either opposed to Christianity or out of all connection with Christianity. Christianity must pervade not merely all nations, but also all of human thought. The Christian, therefore, cannot be indifferent to any branch of earnest human endeavor. It must all be brought into some relation to the gospel. It must be studied either in order to be demonstrated as false, or else in order to be made useful in advancing the Kingdom of God.”
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Born in Baltimore, Maryland, he came from a wealthy and well-educated background. He studied at John Hopkins University and then went to Princeton Theological Seminary, receiving an M.A. in philosophy. He studied in Germany and returned to teach New Testament at Princeton. He received his B.D. in 1905 and was ordained in the Presbyterian Church.
In 1929, he left Princeton Seminary when the institution capitulated to the liberal faction, and he, along with others, founded Westminster Theological Seminary. In 1934 he was censured by the Presbyterian Church for his actions in relation to the Presbyterian Board of Foreign Missions, the liberal bias of which he opposed. In 1935 he was defrocked by the Presbyterian Church over major doctrinal issues. Machen then established the Orthodox Presbyterian Church as a reaction to the liberalism of the Presbyterian hierarchy. He died at age 55, of pneumonia.